244 research outputs found
Security Risk Assessment of Decentralized, Mobile Applications: An Analysis of Location Aware Systems
Technological improvements, declining costs and mandates to suppliers from large entities such as Wal-Mart and the Department of Defense are driving investments in RFID and other location aware systems (LAS). Expected benefits from LAS investments include improvements in supply chain integration and streamlined operations. However, LAS may introduce a number of new information security vulnerabilities into organizations that must be carefully considered. LAS are highly decentralized and mobile, yet must connect to existing transactional systems to function. Decentralized, mobile applications are especially difficult to secure, and connections between LAS and internal applications can put those systems at risk too. The additional complexity of overall systems architectures also makes identifying security risks more challenging. We assert that current guidelines for information security are increasingly insufficient for organizations with highly decentralized systems and that more attention to how systems are employed is needed. We demonstrate this point with logical process models that illustrate how two different uses of one LAS technology result in different information security risks
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THE ECOLOGY OF INTERORGANIZATIONAL INFORMATION SHARING
Increasingly, companies use interorganizational information systems to support business process partnerships, such as automatic replenishment systems and other supply chain initiatives, invoicing and payments, and insurance claims processing. Inter-firm networking in turn can increase the visibility of information generated and used by business partners. These business partners may experience intended and unintended impacts from the changes in the partnering relationship, in effect altering the ecology of the organization. Yet IT researchers rarely study an organization’s ecology, focusing instead on impacts upon internal processes. Our goal in this paper is to propose a definition of interorganizational information ecology, to provide IT researchers with a lens through which interorganizational information sharing should be studied. We begin by reviewing principles of ecology from the natural and social sciences and then discuss the emergence of principles of organizational ecology and information ecology within the management literature. We then argue that advances in information technology have been a primary enabler for companies’ focus on interorganizational business processes and that field research on IT-enabled business partnerships must include the impacts upon each partner and the information shared among them. An example from health care demonstrates the usefulness of the concept, and we conclude with suggestions for field-based research on the ecology of interorganizational information sharing
A Mouse Monoclonal Antibody Against a Newly Discovered Basement Membrane Component, the Epidermolysis Bullosa Acquisita Antigen
A mouse monoclonal antibody, H3a, directed against the newly described epidermolysis bullosa acquisita (EBA) antigen was obtained using hybridoma techniques. The distribution of the monoclonal antibody is identical to that of the polyclonal serum antibody of patients with EBA. By immunofluorescence, a linear band is seen at the dermal-epidermal junction and, by immunoelectron microscopy, immune reaction products are present in the lamina densa and sublamina densa regions. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by Western immunoblot analysis shows that the monoclonal antibody recognizes 290 and 145 kilodalton proteins present in the immunizing junctional extract, identical with the newly discovered EBA antigen. This monoclonal antibody should be useful in the further isolation and characterization of the EBA antigen
First geodetic observations using new VLBI stations ASKAP-29 and WARK12M
We report the results of a successful 7 hour 1.4 GHz VLBI experiment using
two new stations, ASKAP-29 located in Western Australia and WARK12M located on
the North Island of New Zealand. This was the first geodetic VLBI observing
session with the participation of these new stations. We have determined the
positions of ASKAP-29 and WARK12M. Random errors on position estimates are
150-200 mm for the vertical component and 40-50 mm for the horizontal
component. Systematic errors caused by the unmodeled ionosphere path delay may
reach 1.3 m for the vertical component.Comment: 11 pages, 6 flgures, 4 table
Surveying the Dynamic Radio Sky with the Long Wavelength Demonstrator Array
This paper presents a search for radio transients at a frequency of 73.8 MHz
(4 m wavelength) using the all-sky imaging capabilities of the Long Wavelength
Demonstrator Array (LWDA). The LWDA was a 16-dipole phased array telescope,
located on the site of the Very Large Array in New Mexico. The field of view of
the individual dipoles was essentially the entire sky, and the number of
dipoles was sufficiently small that a simple software correlator could be used
to make all-sky images. From 2006 October to 2007 February, we conducted an
all-sky transient search program, acquiring a total of 106 hr of data; the time
sampling varied, being 5 minutes at the start of the program and improving to 2
minutes by the end of the program. We were able to detect solar flares, and in
a special-purpose mode, radio reflections from ionized meteor trails during the
2006 Leonid meteor shower. We detected no transients originating outside of the
solar system above a flux density limit of 500 Jy, equivalent to a limit of no
more than about 10^{-2} events/yr/deg^2, having a pulse energy density >~ 1.5 x
10^{-20} J/m^2/Hz at 73.8 MHz for pulse widths of about 300 s. This event rate
is comparable to that determined from previous all-sky transient searches, but
at a lower frequency than most previous all-sky searches. We believe that the
LWDA illustrates how an all-sky imaging mode could be a useful operational
model for low-frequency instruments such as the Low Frequency Array, the Long
Wavelength Array station, the low-frequency component of the Square Kilometre
Array, and potentially the Lunar Radio Array.Comment: 20 pages; accepted for publication in A
Integrated metagenomic assessment of multiple pre-harvest control points on lettuce resistomes at field-scale
An integrated understanding of factors influencing the occurrence, distribution, and fate of antibiotic resistance genes (ARGs) in vegetable production systems is needed to inform the design and development of strategies for mitigating the potential for antibiotic resistance propagation in the food chain. The goal of the present study was to holistically track antibiotic resistance and associated microbiomes at three distinct pre-harvest control points in an agroecosystem in order to identify the potential impacts of key agricultural management strategies. Samples were collected over the course of a single growing season (67 d) from field-scale plots amended with various organic and inorganic amendments at agronomic rates. Dairy-derived manure and compost amendment samples (n= 14), soil samples (n= 27), and lettuce samples (n= 12) were analyzed via shotgun metagenomics to assess multiple pre-harvest factors as hypothetical control points that shape lettuce resistomes. Pre-harvest factors of interest included manure collection during/post antibiotic use, manure composting, and soil amendment soil with organic (stockpiled manure/compost) versus chemical fertilizer. Microbial community resistome and taxonomic compositions were unique from amendment to soil to lettuce surface according to dissimilarity analysis. The highest resistome alpha diversity (i.e., unique ARGs, n=642) was detected in amendment samples prior to soil application, while the composted manure had the lowest total ARG relative abundance (i.e., 16S rRNA gene-normalized). Regardless of amendment type, soils acted as an apparent ecological buffer, i.e., soil resistome and taxonomic profiles returned to background conditions 120 d-post amendment application. Effects of amendment conditions surprisingly re-emerged in lettuce phyllosphere resistomes, with the highest total ARG relative abundances recovered on the surface of lettuce plants grown in organically-fertilized soils (i.e. compost- and manure-amended soils). Co-occurrence analysis identified 55 unique ARGs found both in the soil amendments and on lettuce surfaces. Among these, arnA and pmrF were the most abundant ARGs co-occurring with mobile genetic elements (MGE). Other prominent ARG-MGE co-occurrences throughout this pre-harvest lettuce production chain included: TetM to transposon (Clostridiodies difficile) in the manure amendment and TriC to plasmid (Ralstonia solanacearum) on the lettuce surfaces. This suggests that, even with imposing manure management and post-amendment wait periods in agricultural systems, ARGs originating from manure can still be found on crop surfaces. This study demonstrates a comprehensive approach to identifying key control points for the propagation of ARGs in vegetable production systems, identifying potential ARG-MGE combinations that could inform future surveillance. The findings suggest that additional pre-harvest and potentially post-harvest interventions may be warranted to minimize risk of propagating antibiotic resistance in the food chain
Evaluation of a clinical decision support strategy to increase seasonal influenza vaccination among hospitalized children before inpatient discharge
Importance: Hospitalized children are at increased risk of influenza-related complications, yet influenza vaccine coverage remains low among this group. Evidence-based strategies about vaccination of vulnerable children during all health care visits are especially important during the COVID-19 pandemic.
Objective: To design and evaluate a clinical decision support (CDS) strategy to increase the proportion of eligible hospitalized children who receive a seasonal influenza vaccine prior to inpatient discharge.
Design, Setting, and Participants: This quality improvement study was conducted among children eligible for the seasonal influenza vaccine who were hospitalized in a tertiary pediatric health system providing care to more than half a million patients annually in 3 hospitals. The study used a sequential crossover design from control to intervention and compared hospitalizations in the intervention group (2019-2020 season with the use of an intervention order set) with concurrent controls (2019-2020 season without use of an intervention order set) and historical controls (2018-2019 season with use of an order set that underwent intervention during the 2019-2020 season).
Interventions: A CDS intervention was developed through a user-centered design process, including (1) placing a default influenza vaccine order into admission order sets for eligible patients, (2) a script to offer the vaccine using a presumptive strategy, and (3) just-in-time education for clinicians addressing vaccine eligibility in the influenza order group with links to further reference material. The intervention was rolled out in a stepwise fashion during the 2019-2020 influenza season.
Main Outcomes and Measures: Proportion of eligible hospitalizations in which 1 or more influenza vaccines were administered prior to discharge.
Results: Among 17 740 hospitalizations (9295 boys [52%]), the mean (SD) age was 8.0 (6.0) years, and the patients were predominantly Black (n = 8943 [50%]) or White (n = 7559 [43%]) and mostly had public insurance (n = 11 274 [64%]). There were 10 997 hospitalizations eligible for the influenza vaccine in the 2019-2020 season. Of these, 5449 (50%) were in the intervention group, and 5548 (50%) were concurrent controls. There were 6743 eligible hospitalizations in 2018-2019 that served as historical controls. Vaccine administration rates were 31% (n = 1676) in the intervention group, 19% (n = 1051) in concurrent controls, and 14% (n = 912) in historical controls (P \u3c .001). In adjusted analyses, the odds of receiving the influenza vaccine were 3.25 (95% CI, 2.94-3.59) times higher in the intervention group and 1.28 (95% CI, 1.15-1.42) times higher in concurrent controls than in historical controls.
Conclusions and Relevance: This quality improvement study suggests that user-centered CDS may be associated with significantly improved influenza vaccination rates among hospitalized children. Stepwise implementation of CDS interventions was a practical method that was used to increase quality improvement rigor through comparison with historical and concurrent controls
The Mysticism Scale as Measure for Subjective Spirituality: New Results with Hood's M-Scale and the Development of a Short Form
Streib H, Klein C, Keller B, Hood RW. The Mysticism Scale as Measure for Subjective Spirituality: New Results with Hood's M-Scale and the Development of a Short Form. In: Ai AL, Harris KA, Wink P, Paloutzian R, eds. Assessing Spirituality and Religion in a Diversified World: Beyond the Mainstream Perspective. New York: Springer; 2021: 45.In this chapter, we suggest the use of Hood’s Mysticism Scale (M-scale) for a differential assessment of subjective spirituality. We base this view on the conceptualization of mysticism and its relation to spirituality, and on the definition of spirituality as individualized experience-orientated religiosity. This perspective was empirically tested in the Bielefeld-based Cross-cultural Study on Spirituality, which explored in comprehensive semantic analyses how participants in the USA and Germany define spirituality and revealed that more spiritual than religious people preferably associate spirituality with experiences of all-connectedness, search for a higher self, existential truth, and humanistic morality. Moreover, structural equations modeling based on this and other recent data sets reveal that the M-scale and its factors have considerable effects on self-rated spirituality. Thus, we recommend the M-scale as measure for subjective spirituality, which avoids the widespread problem of many extant measures that assess spirituality primarily in terms of either (Christian) religiosity or psychosocial well-being. The M-scale may be very useful in research that intends to assess the subjective spirituality of a diversity of participants who might affiliate with various religious traditions and worldviews, including the non-religious, atheists, and non-theists. Besides the well-established 32-item version of the M-scale, the chapter additionally presents an economic 8-item short form of the M-scale and its psychometric properties
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